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Speaker

Stephanie Fretham

Luther College
5633871555
frethams@luther.edu
Dopamine’s relationship with insulin signaling and iron homeostasis
Human, primate, and rodent studies have identified a spectrum of cognitive and behavioral consequences of iron deficiency and iron overload. At the cellular level, iron dyshomeostasis disrupts metabolic, genetic, and structural processes, particularly in highly active cells such as neurons. Many of these processes affected by iron relate directly or indirectly to insulin signaling which influences cellular metabolism, structure, and gene expression and is regulated by extracellular and intracellular factors and responds in a context-dependent manner to iron dyshomeostasis. This talk will focus on experiments in Caenorhabditis elegans (C. elegans) that explore the relationship between iron availability and insulin signaling and its influence on dopamine function.
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